LY-3305677 Introduction
Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.
Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.
Mazdutide is a new type of hypoglycemic and weight-loss product. It is the world's first and currently the only GCG/GLP-1 dual receptor agonist that has been approved for both the treatment of type 2 diabetes and weight management. It is mainly used for blood sugar control in patients with type 2 diabetes and for weight management in overweight or obese individuals. The CAS number of Mazdutide acetate is 2259884-03-0; the EINECS number is 884-103-0.
What are the differences between LY-3305677 and Semaglutide?
Semaglutide is a single-target regulator that only acts on the GLP-1 receptor. It mainly reduces food intake by suppressing appetite and slowing down gastric emptying, achieving weight loss through the principle of "eating less and consuming fewer calories". It belongs to passive calorie control and fat loss.
Mazdutide, on the other hand, operates through a dual-target synergy mechanism, significantly widening the gap in advantages. It can also activate the GLP-1 receptor, suppress appetite, and control calorie intake; at the same time, it can activate the glucagon GCG receptor, directly acting on the liver and fat tissues, actively accelerating fat breakdown and enhancing the body's basal energy consumption. In simple terms: the former is "controlling your mouth", while Mazdutide acetate is both eating less and burning more fat.
The head-to-head clinical comparison data of the two also clearly demonstrate the effect gap: for patients with type 2 diabetes and obesity, after 32 weeks of intervention, nearly 48% of the people in the Mazdutide acetate group achieved blood sugar control + weight loss of more than 10%, while the Semaglutide group only 21%, with a difference of exactly twice in the rate of achieving both goals.
In terms of weight loss, LY-3305677 achieved an average weight loss of 10.3%, much higher than Semaglutide's 6.0%, demonstrating a significant advantage in fat loss effect.
What is the mechanism of action of LY-3305677?
Mazdutide is a dual receptor agonist for GLP-1R and GCGR, exerting metabolic regulatory effects through the "control intake, enhance consumption" bidirectional pathway. After activating the GLP-1 receptor, it can suppress appetite, slow down gastric emptying rate, reduce calorie intake, and regulate INSULIN release according to blood glucose levels, achieving the effect of stabilizing blood sugar; while activating the glucagon receptor can promote fat breakdown and oxidation, increase energy consumption of the body, and optimize the fat metabolism level within the liver. Thanks to this dual-target synergy mechanism, LY-3305677 performs better than most single-target active substances in weight loss and blood sugar control, and also helps regulate blood pressure, blood lipids, blood uric acid, and reduces liver fat accumulation. Relevant studies have also found that Mazdutide acetate may improve cognitive decline associated with diabetes, forming a comprehensive regulatory effect from energy balance to multiple metabolic indicators throughout the body.
MF of Mazdutide acetate
| CAS | 2259884-03-0 |
| Molecular formula | C₂₁₀H₃₂₂N₄₆O₆₇ |
| EINECS | 884-103-0 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Assay | ≥ 98.0% | 99.08% |
| Conclusion | Conform with enterprise specification | |
Click email：sales6@faithfulbio.com Or WhatsApp：+86 17782780648
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Mazdutide etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:Will the combined effect be simply the sum of the individual effects when both targets are activated simultaneously?
It is not a simple addition, but a synergistic effect that achieves the result of "1 + 1 > 2". GLP-1 is responsible for reducing the "input" of energy, while GCG is responsible for increasing the "output" of energy. The combined effect is more significant.
Q2:Who can use LY-3305677?
Indications for weight loss: Individuals with a BMI of 28 kg/m² or higher who are obese; or individuals with a BMI of 24 kg/m² or higher who are overweight and have at least one weight-related comorbidity (such as type 2 diabetes, hypertension, hyperlipidemia, fatty liver, etc.). Indications for diabetes treatment: Adult patients with type 2 diabetes, especially those with overweight/obesity.
Q3:What are the side effects of LY-3305677?
The most common adverse reactions are mild to moderate gastrointestinal symptoms, such as nausea, diarrhea, vomiting, abdominal distension, and constipation. These occur mostly during the dose escalation period and tend to subside as the usage duration increases.
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