Zonisamide Weight Loss CAS 68291-97-4

ad-810, a new broad-spectrum antiepileptic product, was first developed by a major Japanese pharmaceutical company in 1989. It was first approved for listing in Japan in the same year, in the United States in 2000 and in Europe in 2005. This product has been used in Japan and Europe for many years since it went on the market, and the dosage has exceeded 100 million times, so it is a very mature product for treating epilepsy. High-purity Zonisamide weight loss powder is white or yellowish crystalline powder, odorless or slightly odorless, with bitter taste. Almost insoluble in water, in the relevant clinical statistics, this product has a good effect of reducing the weight of patients, but its side effects are also obvious, so the latest research direction of this product is how to safely apply it to the field of weight loss.

What are the mechanisms of Zonisamide weight loss?

The main mechanism of Hot sales Zonisamide raw material in anti-epilepsy is to block the voltage-dependent sodium channel and T-type calcium channel, block the synchronous discharge of neurons and epileptic activity, and inhibit the spread of epileptic seizures. Another potential mechanism is the inhibition of excessive nitric oxide products and free radicals. It is found that It can regulate the formation of cyclic guanosine monophosphate, which is closely related to the origin and spread of epileptic seizures, and can also inhibit lipid peroxidation in epileptic foci caused by iron. These effects can protect neurons from free radical damage and maintain the stability of neuron cell membrane. In clinical practice, it is found that zonisamide can not only make seizures disappear in patients with Parkinson's disease, but also relieve their symptoms of Parkinson's disease. In addition, researchers speculate that the mechanism of Zonisamide weight loss powder is to protect cells from free radical damage by inhibiting lipid peroxidation, and further maintain the activity and stability of cells, which is beneficial to discharge harmful substances during exercise. However, due to the obvious side effects of it, it needs to be used with other linear drugs in general use.

What is the clinical application of Zonisamide Weight Loss?

98% purity Zonisamide will not aggravate cognitive impairment or behavioral or psychological symptoms. It has been reported that zonisamide can activate dopamine synthesis and release in dopaminergic system, inhibit monoamine oxidase B8, block sodium channels and T-type calcium channels in non-dopaminergic system, and improve Parkinson's syndrome in DLB patients.
1. Epilepsy
ci-912 raw powder has been approved in Europe and America for the adjuvant treatment of adult partial seizures, and in Japan for the adjuvant treatment and monotherapy of partial seizures (simple, complex and secondary generalized seizures), generalized seizures (tonic, tonic-clonic (grand mal's) and atypical absence) and complex seizures. In Australia, it is only used for adjuvant therapy and monotherapy of partial seizures. It can be said that ci-912 has a very extensive footprint.

2. Parkinson's disease
In a few countries, it has been approved as an auxiliary drug of levodopa to treat motor symptoms of Parkinson's disease (PD). Since 2009, zonisamide has also been listed as an auxiliary drug in the treatment of levodopa in Japan. After a long period of clinical statistics, there is abundant clinical evidence that zonisamide combined with levodopa is very good in controlling the motor symptoms of PD, but there is relatively little evidence that zonisamide treats the non-motor symptoms of PD at present.

3. Lose weight

The efficacy and safety of compound preparation of zonisamide for weight loss are being evaluated. It is reported that in a clinical phase IIb trial, the subjects who received zonisamide treatment lost 7.5% of their weight, while those who received placebo lost 1.4%(p ≤ 0.001). The most common adverse events of Zonisamide Weight Loss include headache, insomnia and nausea, as well as leukopenia and the increase of alanine aminotransferase and aspartate aminotransferase.

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