Tianeptine Ethyl Ester Introduction
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Tianeptine Ethyl Ester Sulfate is not obtained naturally, but is a tricyclic derivative synthesized through artificial chemical means. CAS Number: 66981-77-9; Molecular formula: C23H29ClN2O4S Molecular weight: 465.01; EINECS Number: 606-227-7 It is mainly applied in laboratory research, quality inspection of pharmaceutical enterprises, and chemical synthesis development, etc.
What is the mechanism of action of Tianeptine Ethyl Ester?
The current research on Tianeptine Ethyl Ester mainly focuses on two aspects: one is to compare the various characteristics of it with the parent product Tianeptine, and the other is to explore the binding pattern between this substance and serum proteins. Based on the existing experimental data, the complete action pathway of this 2-N-BUTOXYETHYL METHACRYLATE derivative in exerting antidepressant effects has not been fully clarified. The overall efficacy logic is significantly different from the prototype Tianeptine.
There is a group of core experiments specifically comparing the binding patterns of the two with bovine serum albumin. Through fluorescence quenching detection, it can be found that Tianeptine relies on dynamic quenching and protein interaction, while Tianeptine Ethyl Ester Sulfate follows the static quenching reaction mode. The molecular docking simulation results also confirm that both substances will have a strong binding force with the albumin IIA site. This also indirectly verifies the static quenching reaction mechanism of the 2-N-BUTOXYETHYL METHACRYLATE derivative. At the same time, this experiment also concludes that because the Tianeptine Ethyl Ester molecule does not contain free acidic groups, its ability to weaken the fluorescence signal of the protein itself is weaker than the prototype Tianeptine.
What is the difference between Tianeptine Ethyl Ester and Tianeptine?
Tianeptine Ethyl Ester and the original Tianeptine are fundamentally different. Tianeptine is a widely approved prescription medication for treating depression, with complete clinical research data. It improves depressive symptoms through a unique action pathway, enhancing the efficiency of 5-Hydroxytryptamine reuptake in the body and also activating μ-opioid receptors. Tianeptine Ethyl Ester Sulfate is merely a derivative obtained through artificial modification and has no clinical approval qualifications. It can only be used for laboratory research analysis and is also a by-product of the production process of Tianeptine raw materials. It has relatively scarce complete pharmacological and safety-related test data.
From a practical usage perspective, Tianeptine Ethyl Ester cannot be regarded as a substitute or optimized version of Tianeptine. The product attributes, actual effects, and safety risks of the two cannot be confused.
MF of Tianeptine Ethyl Ester
| CAS | 66981-77-9 |
| Molecular formula | C23H29ClN2O4S |
| Molecular weight | 465.01 |
| EINECS | 606-227-7 |
| Boiling point | 573.3±60.0 °C |
| Density | 1.30±0.1 g/cm3 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Assay | ≥97.0% | 98.36% |
| Conclusion | Conform with enterprise specification | |
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FAQ:
Q1:Is Tianeptine Ethyl Ester the same as the common antidepressant products?
It's different. SSRI type antidepressant products work by inhibiting the reuptake of Serotonin hydrochloride, while Tianeptine Ethyl Ester actually enhances the reuptake of Serotonin hydrochloride and is a μ-opioid receptor agonist, with completely different mechanisms.
Q2:Does Tianeptine Ethyl Ester have the potential to cause dependence?
It is highly likely. As its parent compound Tianeptine has been proven to have the potential for abuse and addiction, this ethyl derivative also has a similar potential for addiction.
Q3:What is the role of Tianeptine Ethyl Ester in compound detection?
High-purity samples can be used as impurity reference standards. Combined with HPLC testing, they are employed to quantify the content of this impurity in the Tianeptine raw material, thereby ensuring product quality.
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