DM-235 Powder CAS 314728-85-3

Sunifiram is an experimental product that has not been clinically verified, and its development code is DM-235. The field experiments show that it can affect the excitation transmission of choline neurons and promote the synthesis of acetylcholine. It is obviously superior to piracetam in resisting brain function damage caused by physical and chemical factors. In addition, high-purity Sunifiram can alleviate retrograde amnesia caused by hypoxia, and it is also superior to other experimental subjects in improving the learning, memory and recall abilities of experimental monkeys. DM-235 powder is a simplified version of unifiram , but the research of this product has been stopped because of internal disputes of the scientific research team.

What is the pharmacology of DM-235 powder?

It is reported that a wide range of sites have been determined for the experimental body, including the most important receptors, ion channels and transporters, but sunifiram powder has no affinity for any sites. It was tested on recombinant AMPA receptor, and it did not show the enhancement effect on the receptor. The researchers speculated that it could not play a role as a positive allosteric regulator of AMPA receptor.
However, a certain concentration of sunifiram free state can stimulate CaMKII and PKCα pathways, and this effect depends on the activation of glycine site of NMDA receptor. In normal monkey experiments, the popular DM-235 powder can prevent amnesia induced by AMPA receptor antagonist NBQX in passive avoidance test. This also indirectly indicates that the activation of downstream AMPA receptor may be related to its memory enhancement effect. The inhibition of glucose transport in red blood cells can be obviously measured by inputting some products that make people energetic and DM 235 into monkeys.

What is the research on DM-235 powder in cognitive dysfunction after cerebral hemorrhage?

Cerebral hemorrhage is one of the most common and frequent cardiovascular and cerebrovascular diseases in the world, which has the characteristics of high incidence, high disability rate and high mortality. Clinical observation results show that patients with first-episode cerebral hemorrhage are often accompanied by cognitive dysfunction of different degrees, which directly affects the recovery of patients. Therefore, how to effectively improve cognitive dysfunction after cerebral hemorrhage in the elderly has become the focus. Pathological research shows that cognitive dysfunction is mainly caused by brain tissue energy metabolism disorder caused by cerebral ischemia and hypoxia, decreased glucose utilization rate, abnormal protein synthesis, changes in related neurotransmitter levels, loss of cholinergic receptors, white matter damage and neuron defects, etc. Therefore, choosing safe and gentle, reusable and repairing neurons is the key to treat cognitive dysfunction in line with the long evolution law of neurons. According to Sunifiram's related pharmacological research, DM-235 powder only stimulates CaMKII and PKCα pathways, so this product will not impact other normal nerve cells, and this effect of this product depends on the activation of glycine site of NMDA receptor, which can indirectly indicate that its effect is mild and needs to be used in conjunction with body functions. Compared with those products that simply directly affect the living conditions of other neurons and achieve some nootropic effects, the damage to the brain is also negligible. Therefore, in the foreseeable future, high-quality Sunifiram raw material will inevitably occupy an important position in nootropic products.

What should we pay attention to about dm-235 powder?

At present, Sunifiram is in the preclinical research stage, and it is mainly used for the potential treatment of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Therefore, more clinical data are needed for the adverse reactions of DM-235 powder. At present, the known adverse reactions of 98% purity Sunifiram powder to the central nervous system include excitement, irritability, dizziness, headache and insomnia, but the symptoms are mild, which are related to the dosage and time of using it. After stopping, all the above symptoms disappear, and long-term use may lead to a slight increase in transaminase.

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