Ethyl Ferulate CAS 4046-02-0

Ferulic acid ethyl eser Introduction

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Ethyl 4-hydroxy-3-methoxycinnamate is derived from natural Ferulic Acid as the raw material. Its CAS number is 4046-02-0; its molecular formula is C12H14O4; its molecular weight is 222.24; and its EINECS number is 223-745-5. Ferulic Acid is abundantly present in plants such as Angelica sinensis, Ligusticum chuanxiong, and cereal bran. It is an antioxidant substance from natural plant sources. After undergoing esterification processing, it can be transformed into Ethyl ferulate, which has a stronger lipid solubility. It is mainly applied in the fields of skin care, medical research, and the food industry.  

What are the pharmacological effects of Ferulic Acid Ethyl Eser?

Ethyl ferulate can produce various physiological effects such as antioxidation, anti-inflammation, and neuroprotection. Its action targets cover multiple cell signaling pathways, and its mechanism is rather diverse.
The most core characteristic of this substance is its efficient upregulation of heme oxygenase-1, which can significantly enhance the gene transcription, protein content, and enzyme catalytic activity of HO-1 within cells. It builds an antioxidant defense barrier within neurons and astrocytes to counteract the cell damage caused by oxidative stress. From the perspective of molecular action logic, it can undergo covalent modification with the Cys151 site on the Keap1 protein, thereby activating the Nrf2/ARE antioxidant response pathway and driving the synchronous expression of various antioxidant-related genes, thereby strengthening the cell's own antioxidant capacity.
For inflammatory-related responses, it mainly relies on regulating two pathways, NF-κB and MAPK, to reduce the release of various pro-inflammatory factors; at the same time, it can directly bind and block the activity of monoamine oxidase B (MAO-B), alleviating the inflammatory response in neural tissues. Existing experiments have also confirmed that it can inhibit the activation of the TGFBR1 pathway, improving myocardial fibrosis-related lesions; in addition, by downregulating the activity of the mTOR pathway, it has an inhibitory effect on the proliferation of tumor cells.
Overall, Ethyl 4-hydroxy-3-methoxycinnamate achieves a wide variety of physiological activities by simultaneously acting on multiple protein targets and regulating multiple signaling pathways. This is also the fundamental reason for its broad pharmacological action coverage.

What is the use of ferulic acid ethyl eser?

The current practical applications of Ethyl 4-hydroxy-3-methoxycinnamate mainly fall into three categories: skincare ingredients, pharmaceutical research, and food preservation.
As a skincare ingredient, this component demonstrates outstanding antioxidant, free radical removal, and UV-blocking capabilities. It is commonly blended into sunscreen, anti-aging, and lightening essence and cream products, with the industry's standard addition range maintained at 0.5% to 1%.
In the pharmaceutical sector, Ethyl ferulate can serve as a basic raw material for cardiovascular and cerebrovascular, and white blood cell reduction-related preparations. A large number of experiments have also verified its protective effect on nerve cells; this substance can stimulate the expression of HO-1 protein, helping cells resist oxidative damage, and effectively down-regulate various inflammatory responses.
In the food preservation direction, current research is mainly focused on theoretical studies. The industry is attempting to develop specialized natural preservatives for fruits and vegetables by relying on Ferulic acid ethyl eser. It can inhibit the operation of lipoxygenase, reduce ethylene secretion, and slow down the aging process of fruits and vegetables; in addition, experimental data shows that this substance has inhibitory effects on various fungi that infect fruits and vegetables after harvest, and has the potential to be used as a natural preservative for post-harvest fruits and vegetables.

MF of Ferulic acid ethyl eser

CAS	4046-02-0
Molecular formula	C12H14O4
Molecular weight	222.24
EINECS	223-745-5
Boiling point	63-65 °C
Density	1.0643

Specification

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FAQ: 

Q1:Is ferulic acid ethyl eser safe to use in cosmetics?
It is safe at the recommended concentration. It has been included in the "Catalogue of Cosmetics Raw Materials that Have Been Used". The historical maximum usage in long-lasting products can reach 0.7%. However, pure raw materials may cause mild irritation to the skin and eyes. Proper protection should be taken during the application process.
Q2:In which products is ferulic acid ethyl ester usually used?
In skin care products, it is commonly used in sunscreen lotions, anti-aging essences, whitening and pigmentation removal products, as well as various emulsions and creams. It is usually added at a concentration ranging from 0.1% to 1%.
Q3:Can ferulic acid ethyl eser be used in combination with other ingredients?

OK. In cosmetic formulations, it is often used in combination with classic antioxidants such as vitamin C and vitamin E to enhance the overall antioxidant network protection effect. Its stable chemical properties make it highly compatible in the compound system.

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