what is 10-HDA?
10-HDA is the main active ingredient in royal jelly and the most important indicator for measuring the quality of royal jelly. Colorless needle shaped crystal, melting point 66-67 ℃, easily soluble in organic solvents, difficult to dissolve in water.
|
|
Product name |
10-HDA |
|
CAS |
14113-05-4 |
|
|
Molecular formula |
C10H18O3 | |
| EINECS | 808-119-7 | |
|
Molecular weight |
186.25 | |
| Melting point | 64.0 to 68.0 °C | |
|
Appearance |
white crystalline powder |
|
| Density | 1.038±0.06 g/cm3(Predicted) |
What are the main uses of 10-HDA?
|
|
Queen been acid is a substance with significant physiological activity, which has the functions of enhancing the body's resistance, resisting bacteria and inflammation, and strongly inhibiting multiple cells such as lymph cancer and breast cancer. It also has the functions of strengthening the body, preventing hair loss, and treating acute radiation damage and chemical damage. 10-HDA has strong antibacterial effects on Escherichia coli and pyogenic cocci. It can protect and restore the core substances of life - proteins, ribonucleic acid, and deoxyribonucleic acid in the internal organs. It has good therapeutic effects on hyperlipidemia, cirrhosis, and cellular anemia. The combination of Queen been acid with chemotherapy and radiotherapy for the treatment of malignant tumor patients has a significant effect on improving the body's immunity, increasing white blood cells, and improving clinical symptoms. It can reduce the content of triglycerides in plasma and improve clinical symptoms. |
| 10-HDA also has the function of regulating cell growth and promoting cell differentiation, and is commonly used in the production of health products to increase nutritional and health functions.If you need it, pls click e-mailsales1@faithfulbio.com |
How does 10-HDA repair the skin barrier and resist aging?
|
|
Some findings substantiated that 10-HDA promoted the differentiation of epidermal cells, reinforcing the cornified envelope assembly. 10-Hydroxy-2-decenoic acid promotes expression of intercellular lipids, after 10-HDA intervention, the expression levels of ceramides and fatty acids increased Genomic instability, a key characteristic of skin aging, is often exacerbated by DNA damage induced by UV radiation.Queen been acid can Anti-aging through alleviating DNA damage and enhancing mitochondrial function in HSF cells |
Product Specification
|
Item |
Specifications |
Results |
|
Appearance |
White to off-white crystalline powder |
Conforms |
|
Identification |
Conforms |
Conforms |
| Partical size | 100% through 80mesh | Conforms |
| Purity |
98 ~ 102% |
98.8% |
how to synthesize 10-HDA?
|
|
select brewing yeast S. cerevisiae BY4741 as the host strain, pESC-URA as the expression vector, and added auxiliary protein genes sil1P and cpr5P, respectively, to construct recombinant plasmids pESC-URA-M228L(A), pESC-URA-M228L-sil1P(B) and pESC-URA-M228L-cpr5P( C). They were introduced into S. cerevisiae BY4741 to form recombinant yeast strains S. cerevisiae BY4741-pESC-URA CYP153A33/M228L-CPRBM3, S. cerevisiae BY4741-pESC-URA CYP153A33/M228L-CPRBM3-sil1P, and S. cerevisiae BY4741-pESC-URA CYP153A33/M228L-CPRBM3-cpr5P, respectively. 10-HDA was prepared by fermentation using trans-2-decenoic acid as the substrate. Yeast engineered strains were separately inoculated into a pH 5.0–6.0 uracil deficient seed culture medium, and incubated overnight at 25–35 °C. The seed liquid was incubated with an initial OD600 of 0.4 until the OD600 was 1.0–1.2. The yeast cells were collected by centrifugation at 3500–4000 rpm for 10–15 min, and resuspended in uracil deficient fermentation medium. 0.5g/L trans-2-decenoic acid was added to the medium, and incubated at 25–35 °C for 72 h to prepare royal jelly acid. |
In more details, the engineered yeast was transferred to an SD-URA medium using plate streaking, and it was incubated at 30 °C for 56 h. A single colony was then selected and cultured in a liquid medium, followed by overnight incubation at 30 °C and 220 rpm to generate the seed liquid. Subsequently, the seed solution was inoculated into a liquid medium containing trans-2-decenoic acid (OD = 0.4) and cultured for 24 h. The supernatant was collected, and the pH was adjusted to 11–12 using 20 % NaOH. The mixture was left to separate for 1–4 h. The supernatant was then filtered through 0.22 μm and 300-Da ultrafiltration membranes, and the filtrate was collected. Activated carbon was added for decolorization for 1 h. The solution was transferred to the plate and frame filtration device to collect the filtrate. The pH was adjusted to 2.0–3.0 with 1 mol/L H2SO4, cooled to 20 °C, and crystallized for 5 h to allow the effective ingredients to crystallize and precipitate. The solution was then transferred again to the plate and frame filtration device to collect the filter cake. It was dissolved in 95 % ethanol, diluted with three times the volume of deionized water, and the filter cake was collected again after crystallization. The filter cake was placed in a vacuum dryer, and the temperature was raised to 40–50 °C. Drying for 1–4 h resulted in the production of 10-HDA (D).
How and where to buy 10-HDA?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q: What are the sources of 10-HDA?
A:10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.
Q: What is the structure of Queen been acid?
A:10-HDA is an inherent trans unsaturated fatty acid in royal jelly, its chemical structure is HO-CH2–(CH2) 6-CH = CH-COOH (C10H18O3), with a molecular weight of 186.25.
Q: Can humans eat royal jelly?
A: When taken by mouth: Royal jelly is possibly safe when used short-term. Doses of up to 4.8 grams daily have been used safely for up to 1 year. It's usually well-tolerated. But people with asthma or allergies might experience an allergic reaction.
Disclaimer: The articles on this website are mainly used for scientific research and academic exchange. Please carefully discern the authenticity of their viewpoints and content. If you discover any infringement. Please contact the administrator promptly. We are not responsible for the consequences of the information and services provided on this website.
Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
Hot Tags: 10-hda cas 14113-05-4, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China