1,3-Dihydroxyacetone Raw Powder CAS 96-26-4

1,3-Dihydroxyacetone (DHA) is the main active ingredient in sunless tanning skin care products because of its reducibility. Pure dihydroxyacetone is a naturally occurring polyhydroxyketose (also the simplest ketose known at present), which is biodegradable, with a white powdery crystal appearance, easily soluble in water and other organic solvents, such as ethanol, ether and acetone, and its water solubility is more than 250 g/L (20℃). It is an edible multifunctional additive. At present, the usual production method is obtained by microbial fermentation of Gluconobacter oxydans.

How to obtain 1,3-Dihydroxyacetone?

1,3-Dihydroxyacetone Raw Powder is mainly obtained by chemical synthesis and microbial fermentation. Among them, the microbial fermentation of glycerol by Gluconobacter oxydans has obvious advantages, such as high product concentration, high glycerol conversion rate and low production cost. Therefore, it has become the optimal solution of factory selection in the world. In contrast, the chemical method in the laboratory research stage can only provide products for research institutions and university laboratories, but its advantage is that it can make up for the long production cycle of microbial fermentation and the high requirements of production environment. Let's briefly introduce the three most mainstream chemical synthesis methods:

1.1,3- dihydroxyacetone was synthesized from 1,3- dichloroacetone and ethylene glycol through carbonyl protection, etherification, hydrogenolysis and hydrolysis.1,3- dichloroacetone and ethylene glycol are heated and refluxed in toluene to dehydrate to generate 2,2- dichloromethyl -1,3- dioxolane, and then react with sodium benzyl alcohol in N,N- dimethylformamide to generate 2,2- dibenzyloxy -1,3- dioxolane.1,3- dioxolane -2,2- dimethyl alcohol was synthesized by hydrogenolysis under the catalysis of Pd/C, and then hydrolyzed in hydrochloric acid to produce 1,3- dihydroxyacetone.

The raw materials for synthesizing 1,3- dihydroxyacetone by this method are easily available, the reaction conditions are mild, and the Pd/C catalyst can be recycled, which has important application value.

2. 1,3- dihydroxyacetone was synthesized from 1,3- dichloroacetone and methanol by carbonyl protection, etherification, hydrogenolysis and hydrolysis.1,3- dichloroacetone reacts with excess anhydrous methanol in the presence of water absorbent to generate 2,2- dimethoxy -1,3- dichloropropane, and then reacts with sodium benzyl alcohol in N,N- dimethylformamide to generate 2,2- dimethoxy -1,3- dibenzyloxy propane. 2,2- dimethoxy -1,3- propylene glycol is produced by hydrogenolysis under the catalysis of Pd/C, and then it is hydrolyzed in hydrochloric acid to produce 1,3- dihydroxyacetone.

This route changes the carbonyl protective agent from ethylene glycol to methanol, which makes the product 1,3- dihydroxyacetone easier to separate and purify, and has important development and application value.

3.3. Synthesize 1,3-dihydroxyacetone using acetone, methanol, chlorine or bromine as the main raw materials. Acetone, anhydrous methanol, and chlorine or bromine are used in a one pot method to produce 2,2-dimethoxy-1,3-dichloropropane or 1,3-dibromo-2,2-dimethoxypropane, which is then etherified with sodium benzyl alcohol to produce 2,2-dimethoxy-1,3-dibenzyloxypropane. After hydrogenation and hydrolysis, 1,3-dihydroxyacetone is produced.

The reaction conditions of this route are mild, and the "one-pot" reaction avoids the use of 1,3- dichloroacetone, which is expensive and irritating, so that this route has low cost and high development value.

Product Specification

How do I use dihydroxyacetone?

1. When 1,3-dihydroxyacetone is used as the formula raw material of cosmetics, besides the functions of conventional moisturizing and sunscreen products, the ketone functional groups in DHA can react with amino acids and amino groups of skin keratin to form brown polymers, just like healthy skin that has been dried in the sun for a long time. However, it should be noted that SCCS evaluation shows that DHA with a concentration of less than 10% is safe to use in cosmetics, and DHA with a concentration of less than 6.25% is safe to use in resident (non-oxidized) hair-dyeing cosmetics, and there is no danger in combination. In addition, it is safe to use DHA with a concentration not exceeding 14% as sunscreen spray cosmetics.

2.An experimental team has proved that adding a certain amount of mixture of DHA and pyruvate (calcium salt) into pig feed (about 3: 1 weight ratio) can reduce the fat content of pig back meat by 12%~ 15%, the fat content of leg meat also decreases correspondingly, and the protein content increases by 3%. At the same time, the experimental team used the mixture of DHA and pyruvate (calcium salt) in other animals, and found that different proportions of this product had excellent effects on slimming and bodybuilding of animals. However, there is no more detailed scientific demonstration at present, so further experimental verification is needed.

3.If athletes use moderate amounts of 1,3-Dihydroxyacetone Raw Powder during aerobic endurance exercises, it can supplement dihydroxyacetone (especially in combination with pyruvic acid) to increase the body's metabolic rate and fatty acid oxidation, potentially and effectively burning fat and reducing body fat content. It can also improve insulin sensitivity and reduce plasma cholesterol levels caused by high cholesterol diets. Long term supplementation can increase blood glucose utilization and save muscle glycogen

The dihydroxyacetone is a versatile product. Besides the above three points, DHA can be used as a protective agent for leather products if it is used in leather industry. If this product is used in food preservation, it can prolong the storage time of fruits and vegetables, aquatic products and meat products; In chicken embryo culture, it can also be used as an antiviral agent to inhibit the infection of chicken plague virus and so on.

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Note： All compounds are at risk. Please consult your tutor, doctor, or other researchers before use. This product is not used to diagnose, prevent or treat any disease, but only for scientific research. The company is not responsible for the consequences of improper use.

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