What is Hygromycin A?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Hygromycin A (CAS 6379‑56‑2) is a natural secondary metabolite from Streptomyces hygroscopicus. This research‑focused small organic molecule has a molecular formula of C₂₃H₂₉NO₁₂ and molecular weight 511.48, presenting as white to pale‑yellow solid powder.
Soluble well in water and alcohol solvents and partially soluble in neutral buffers, it can be easily configured into working solutions of different concentrations for experiments. It interferes with microbial protein synthesis by acting on the peptidyl transferase region of ribosomes. It effectively restrains the growth of specific spirochetes and is widely applied in molecular biology and microbial mechanism‑related research work.
Application of Hygromycin A
Hygromycin A (CAS 6379-56-2) is primarily used in multi-faceted laboratory research. Leveraging its ability to act on ribosomes and interfere with protein synthesis, it is frequently used to investigate the growth mechanisms of spirochetal microorganisms. This includes experiments involving in vitro microbial culture and observation of microbial community changes in model systems. It is also used to study the fundamental molecular mechanisms of ribosome function and protein translation, elucidating the interaction patterns between small molecules and ribosomes. Furthermore, this substance can be used in natural product research, helping to uncover the structure-activity relationships of active molecules derived from Streptomyces, and providing reference materials for the structural modification of similar molecules and the development of new functional molecules.
COA
| Test Item | Specification | Test Result |
| Appearance | White to light yellow solid powder |
White light yellow solid powder |
| Purity(HPLC) | ≥98.0% | 98.62% |
| Loss on Drying | ≤2.0% | 0.85% |
| Residue on Ignition | ≤0.5% | 0.21% |
| Heavy Metals | ≤10 ppm | Conforms |
| Conclusion | Conform with enterprise specification | |
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Molecular Formula: C23H29NO12
Molecular Weight: 511.48
Exact Mass: 511.16900
PSA: 207.96000
InChIKey: YQYJSBFKSSDGFO-MZHPCZETNA-N
Mechanism of action of Hygromycin A
Hygromycin A occupies the peptidyl transferase center within microbial 70S ribosomes via binding to this functional locus.
It lowers peptidyl transferase catalytic activity, resulting in direct disruption of peptide‑bond generation.
Peptide chain elongation is blocked, so microorganisms cannot carry out complete protein synthesis.
Disruption of the standard ribosome translation cycle leads to suppression of microbial growth and reproduction.
Hygromycin A and Hygromycin B do not share identical ribosome‑binding positions; their working mechanisms show substantial divergence.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. Where does hygromycin A originate?
Hygromycin A is a natural secondary metabolite produced by the fermentation of Streptomyces hygromycin.
02. What are the storage requirements for hygromycin A?
The solid powder is recommended to be stored at -20°C in a sealed container, protected from light; it can tolerate room temperature during short-distance transport.
03. Are hygromycin A and Hygromycin B the same substance?
No, they are not the same substance. Their CAS numbers, molecular structures, and ribosome binding sites are all different, and they cannot be used interchangeably in experimental settings.
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Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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